The following is a lightly edited transcription of what one couple on the street told me about addiction, addictive behavior, and medication-assisted treatment. These posts are about the everyday words and worlds of my friends, not the “issues” they may raise.
The naloxone in suboxone is not active when taken sublingually. It is there to protect the person who melts a strip or dissolves a tab to inject, to prevent overdose. The bupenorphrine component is a partial opioid agonist. It binds to the receptors that typically produce a high, rendering other opioids ineffective at getting one high. It also takes away withdrawal symptoms, it’s primary purpose.
Thanks Shawn for the clarity. As I think you can see, I've struggled the understand the nuances of M.A.T. I see post was written a year ago and I've learned more since then. As I understand it Suboxone also t protects a person who wants to "top off" with a little opioid because it would make them go into instant withdrawal. (Whereas they can top off methadone and even use as a substitute when they screw up on their clinic dosing. I've also heard that some former(?) addicts or experimenters can get high off Suboxone. if they take enough. Also there's Subutex which has buprenorphine without the Naloxone. I was also surprised to learn how much methadone and Naloxone people don't use ['cause they can get by withless] so they can sell it on the street. Let me know if any of this sounds off.
Sorry for the late reply. I don’t look at my app very often. I do know that buprenorphine has a “ceiling” effect. The average dosing is 12-16 mg/day I believe. If you take more, up to a total of 24 mg you might feel a slight high, but going above 24 mg will not feel more high than 24 when you’ve hit it’s ceiling. Bup saved my life. I wish it was more easily available. Providers need special training and certification and are limited to 100 patients each.
Nice mild fall we've been having. Hope all's well!
Interesting topic , though I too am perplexed about how all these "meds" work. This article, about a concept/program conceived by my cousin John Brooklyn, who's based in Burlington, may shed some light!
The naloxone in suboxone is not active when taken sublingually. It is there to protect the person who melts a strip or dissolves a tab to inject, to prevent overdose. The bupenorphrine component is a partial opioid agonist. It binds to the receptors that typically produce a high, rendering other opioids ineffective at getting one high. It also takes away withdrawal symptoms, it’s primary purpose.
Thanks Shawn for the clarity. As I think you can see, I've struggled the understand the nuances of M.A.T. I see post was written a year ago and I've learned more since then. As I understand it Suboxone also t protects a person who wants to "top off" with a little opioid because it would make them go into instant withdrawal. (Whereas they can top off methadone and even use as a substitute when they screw up on their clinic dosing. I've also heard that some former(?) addicts or experimenters can get high off Suboxone. if they take enough. Also there's Subutex which has buprenorphine without the Naloxone. I was also surprised to learn how much methadone and Naloxone people don't use ['cause they can get by withless] so they can sell it on the street. Let me know if any of this sounds off.
Sorry for the late reply. I don’t look at my app very often. I do know that buprenorphine has a “ceiling” effect. The average dosing is 12-16 mg/day I believe. If you take more, up to a total of 24 mg you might feel a slight high, but going above 24 mg will not feel more high than 24 when you’ve hit it’s ceiling. Bup saved my life. I wish it was more easily available. Providers need special training and certification and are limited to 100 patients each.
https://www.med.uvm.edu/vtmedicine/summer_2018/inventing-the-wheel
Hey David,
Nice mild fall we've been having. Hope all's well!
Interesting topic , though I too am perplexed about how all these "meds" work. This article, about a concept/program conceived by my cousin John Brooklyn, who's based in Burlington, may shed some light!
Bidi x